Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder
Identifieur interne : 000562 ( Main/Exploration ); précédent : 000561; suivant : 000563Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder
Auteurs : Xiaobin Zhang [France, République populaire de Chine] ; Joanna Norton [France] ; Isabelle Carrière [France] ; Karen Ritchie [France, Royaume-Uni] ; Isabelle Chaudieu [France] ; Joanne Ryan [France, Australie] ; Marie-Laure Ancelin [France]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (
Url:
DOI: 10.1038/srep42676
PubMed: 28198454
PubMed Central: 5309880
Affiliations:
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xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Inserm</institution>, U1061, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ Montpellier</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Inserm</institution>, U1061, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ Montpellier</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Faculty of Medicine, Imperial College</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Inserm</institution>, U1061, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ Montpellier</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Inserm</institution>, U1061, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ Montpellier</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Disease Epigenetics Group, Murdoch Children’s Research Institute, and Department of Paediatrics, The University of Melbourne</institution>, Parkville,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Inserm</institution>, U1061, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Univ Montpellier</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (<italic>ADRs</italic>) with GAD, with the involvement of stressful events. Data were obtained from 844 French community-dwelling elderly aged 65 or over. Anxiety disorders were assessed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. Eight single-nucleotide polymorphisms (SNPs) involved with adrenergic function were genotyped; adrenergic receptors alpha(1A) (<italic>ADRA1A</italic>), alpha(2A) (<italic>ADRA2A</italic>), and beta2 (<italic>ADRB2</italic>) and transcription factor <italic>TCF7L2</italic>. Questionnaires evaluated recent stressful life events as well as early environment during childhood and adolescence. Using multivariate logistic regression analyses four SNPs were significantly associated with GAD. A 4-fold modified risk was found with <italic>ADRA1A rs17426222</italic> and <italic>rs573514,</italic> and <italic>ADRB2 rs1042713</italic> which remained significant after Bonferroni correction. Certain variants may moderate the effect of adverse life events on the risk of GAD. Replication in larger samples is needed due to the small case number. This is the first study showing that <italic>ADR</italic> variants are susceptibility factors for GAD, further highlighting the critical role of the adrenergic nervous system in this disorder.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hoge, E A" uniqKey="Hoge E">E. A. Hoge</name></author><author><name sortKey="Ivkovic, A" uniqKey="Ivkovic A">A. Ivkovic</name></author><author><name sortKey="Fricchione, G L" uniqKey="Fricchione G">G. L. Fricchione</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. 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Durham</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country></list><tree><country name="France"><noRegion><name sortKey="Zhang, Xiaobin" sort="Zhang, Xiaobin" uniqKey="Zhang X" first="Xiaobin" last="Zhang">Xiaobin Zhang</name></noRegion><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name><name sortKey="Norton, Joanna" sort="Norton, Joanna" uniqKey="Norton J" first="Joanna" last="Norton">Joanna Norton</name><name sortKey="Norton, Joanna" sort="Norton, Joanna" uniqKey="Norton J" first="Joanna" last="Norton">Joanna Norton</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><name sortKey="Zhang, Xiaobin" sort="Zhang, Xiaobin" uniqKey="Zhang X" first="Xiaobin" last="Zhang">Xiaobin Zhang</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Xiaobin" sort="Zhang, Xiaobin" uniqKey="Zhang X" first="Xiaobin" last="Zhang">Xiaobin Zhang</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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